Sandbox2 Eric Martz: Difference between revisions
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CD8:D T30.OG1 : T225.O HLA-A2:A 2.7 Å | CD8:D T30.OG1 : T225.O HLA-A2:A 2.7 Å | ||
CD8:E S34.OG : Q226.NE2 3.0 | CD8:E S34.OG : Q226.NE2 3.0 | ||
CD8:D N99.OD1 : L230.N 3.0 | |||
CD8:D N99.ND2 : L230.O 3.4 | |||
CD8:D S27.OG1 : E232.OE1 2.7 | CD8:D S27.OG1 : E232.OE1 2.7 | ||
Revision as of 22:46, 18 March 2009
This page contains a collaboration between User:Eric Martz and the ConSurf Team. Please edit this page only if you are a participant in this collaboration. Thank you.
In MHC Class I (mouse and human) Q226 is part of the binding site for CD8[1]. Regarding the alpha chain (A) in human MHC 1akj, the authors state:
A flexible loop of the alpha3 domain (residues 223-229) is clamped between the complementarity-determining region (CDR)-like loops of the two CD8 subunits in the classic manner of an antibody-antigen interaction ....
Hydrogen bonds between CD8 and the alpha chain of HLA-A2 that involve this loop are (from Table 2[1]):
CD8:D T30.OG1 : T225.O HLA-A2:A 2.7 Å CD8:E S34.OG : Q226.NE2 3.0 CD8:D N99.OD1 : L230.N 3.0 CD8:D N99.ND2 : L230.O 3.4 CD8:D S27.OG1 : E232.OE1 2.7
| 2VAA chain A | |||
| Server | Sequences | Q226* | APD |
|---|---|---|---|
| ConSurf-DB | 144 | 4 | 1.72 |
ReferencesReferences
- ↑ 1.0 1.1 Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355 doi:http://dx.doi.org/10.1038/42523