Sandbox2 Eric Martz: Difference between revisions
Jump to navigation
Jump to search
Eric Martz (talk | contribs) x |
Eric Martz (talk | contribs) x |
||
| Line 7: | Line 7: | ||
</blockquote> | </blockquote> | ||
Hydrogen bonds between CD8 and the alpha chain of HLA-A2 that involve this loop are (from Table 2<ref name="gao" />): | |||
<pre> | |||
CD8.A T30.OG1 : T225.O HLA-A2:A | |||
</pre> | |||
{| class="wikitable" | {| class="wikitable" | ||
Revision as of 22:24, 18 March 2009
This page contains a collaboration between User:Eric Martz and the ConSurf Team. Please edit this page only if you are a participant in this collaboration. Thank you.
In MHC Class I (mouse and human) Q226 is part of the binding site for CD8[1]. Regarding the alpha chain (A) in human MHC 1akj, the authors state:
A flexible loop of the alpha3 domain (residues 223-229) is clamped between the complementarity-determining region (CDR)-like loops of the two CD8 subunits in the classic manner of an antibody-antigen interaction ....
Hydrogen bonds between CD8 and the alpha chain of HLA-A2 that involve this loop are (from Table 2[1]):
CD8.A T30.OG1 : T225.O HLA-A2:A
| 2VAA chain A | |||
| Server | Sequences | Q226* | APD |
|---|---|---|---|
| ConSurf-DB | 144 | 4 | 1.72 |
ReferencesReferences
- ↑ 1.0 1.1 Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355 doi:http://dx.doi.org/10.1038/42523