Sandbox315: Difference between revisions
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Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. | Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. | ||
<scene name='Sandbox315/Beta_sheet/1'>Beta Sheet</scene> | |||
Reference[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-457CY1P-6G&_user=1516330&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053443&_version=1&_urlVersion=0&_userid=1516330&md5=374e1e8bd2911c09295d019540f42bca] | Reference[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-457CY1P-6G&_user=1516330&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053443&_version=1&_urlVersion=0&_userid=1516330&md5=374e1e8bd2911c09295d019540f42bca] | ||