3g0f: Difference between revisions

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New page: '''Unreleased structure''' The entry 3g0f is ON HOLD Authors: Gajiwala, K.S., Wu, J.C., Lunney, E.A., Demetri, G.D. Description: KIT kinase domain mutant D816H in complex with sunitini...
 
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'''Unreleased structure'''
{{Seed}}
[[Image:3g0f.jpg|left|200px]]


The entry 3g0f is ON HOLD
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{{STRUCTURE_3g0f|  PDB=3g0f |  SCENE=  }}


Authors: Gajiwala, K.S., Wu, J.C., Lunney, E.A., Demetri, G.D.
===KIT kinase domain mutant D816H in complex with sunitinib===


Description: KIT kinase domain mutant D816H in complex with sunitinib


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:36:19 2009''
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{{ABSTRACT_PUBMED_19164557}}
 
==Disease==
Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Germ cell tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mast cell leukemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mastocytosis with associated hematologic disorder OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Piebaldism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]]
 
==About this Structure==
3G0F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G0F OCA].
 
==Reference==
<ref group="xtra">PMID:19164557</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Demetri, G D.]]
[[Category: Gajiwala, K S.]]
[[Category: Lunney, E A.]]
[[Category: Wu, J C.]]
[[Category: Atp-binding]]
[[Category: Disease mutation]]
[[Category: Drug resistance]]
[[Category: Glycoprotein]]
[[Category: Immunoglobulin domain]]
[[Category: Kinase]]
[[Category: Kit kinase domain]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Proto-oncogene]]
[[Category: Receptor]]
[[Category: Sutent binding]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:36:41 2009''

Revision as of 10:36, 25 February 2009

File:3g0f.jpg

Template:STRUCTURE 3g0f

KIT kinase domain mutant D816H in complex with sunitinibKIT kinase domain mutant D816H in complex with sunitinib

Template:ABSTRACT PUBMED 19164557

DiseaseDisease

Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[164920], Germ cell tumors OMIM:[164920], Leukemia, acute myeloid OMIM:[164920], Mast cell leukemia OMIM:[164920], Mastocytosis with associated hematologic disorder OMIM:[164920], Piebaldism OMIM:[164920]

About this StructureAbout this Structure

3G0F is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Gajiwala KS, Wu JC, Christensen J, Deshmukh GD, Diehl W, Dinitto JP, English JM, Greig MJ, He YA, Jacques SL, Lunney EA, McTigue M, Molina D, Quenzer T, Wells PA, Yu X, Zhang Y, Zou A, Emmett MR, Marshall AG, Zhang HM, Demetri GD. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1542-7. Epub 2009 Jan 21. PMID:19164557

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