Sandbox Eric Martz: Difference between revisions
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from a Cullin-RING ligase <b>dimer</b> ([[3dpl]]) to the <b>trimer</b> resulting from NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to Lys724 of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by the RING N-terminus which remains embedded in Cullin. ''The contraction and re-expansion of the C-terminal domain during rotation is an artifact of the morphing algorithm.'' | from a Cullin-RING ligase <b>dimer</b> ([[3dpl]]) to the <b>trimer</b> resulting from NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to Lys724 of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by the RING N-terminus which remains embedded in Cullin. ''The contraction and re-expansion of the C-terminal domain during rotation is an artifact of the morphing algorithm.'' | ||
<applet load='3dqv_trimer1_trimer2_morph.pdb.gz' size='500' frame='true' align='right' | |||
caption='Two trimers in the asymmetric unit of 3dqv.' /> | |||
<applet load='3dqv_trimer1_trimer2_morph.pdb.gz' size='500' frame='true' align='right' caption='Two trimers in the asymmetric unit of 3dqv.' /> | |||
Hello | Hello | ||
{{Clear}} | {{Clear}} | ||
==Notes and References== | ==Notes and References== | ||
<references /> | <references /> | ||