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Proposed article title: Release of RING from Cullin by NEDD8ylation | Proposed article title: Release of RING from Cullin by NEDD8ylation | ||
<applet load=' | <applet load='3dpl_3dqv_acr_morph.pdb' size='500' frame='true' align='right' caption='Insert caption here' /> | ||
At right is a morph<ref>[[Image:3dpl_3dqv_acr_morph.pdb]]</ref><ref>Methods</ref> from a Cullin-RING ligase complex ([[3dpl]]) to the same complex after NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to LysXXX of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by a coil at the RING X-terminus which is embedded in Cullin. | At right is a morph | ||
<ref>[[Image:3dpl_3dqv_acr_morph.pdb]]</ref> | |||
<ref>Methods</ref> | |||
from a Cullin-RING ligase complex ([[3dpl]]) to the same complex after NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to LysXXX of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by a coil at the RING X-terminus which is embedded in Cullin. | |||
==Notes and References== | ==Notes and References== | ||
<references /> | <references /> | ||
Revision as of 06:17, 22 February 2009
This article is under collaborative development by Eric Martz (UMass) and Raymond J. Deshaies and his team (CalTech). Please do not edit this page unless you are a member of the development team.. Once completed, this page may be moved to a permanent article title.
Proposed article title: Release of RING from Cullin by NEDD8ylation
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At right is a morph [1] [2] from a Cullin-RING ligase complex (3dpl) to the same complex after NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to LysXXX of Cullin; 3dqv). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by a coil at the RING X-terminus which is embedded in Cullin.
Notes and ReferencesNotes and References
- ↑ File:3dpl 3dqv acr morph.pdb
- ↑ Methods