Aconitase: Difference between revisions
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Ralf Stephan (talk | contribs) catalytic applet, two scenes |
Ralf Stephan (talk | contribs) |
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== Catalytic mechanism of mitochondrial ACO == | == Catalytic mechanism of mitochondrial ACO == | ||
<applet load=7acn scene='Aconitase/7acn-sf4/1' size='400' frame='true' align='left' caption="Mitochondrial aconitase from pig, PDB [[7acn]]." />The bulk of citrate cycle processing happens in mitochondria and so, studies concentrated on the mitochondrial ACO. The <scene name='Aconitase/7acn-sf4-3cys/1'>(4Fe-4S) cofactor is held in place</scene> by three sulfur atoms belonging to the cysteins-385, -448, and -451. | <applet load=7acn scene='Aconitase/7acn-sf4/1' size='400' frame='true' align='left' caption="Mitochondrial aconitase from pig, PDB [[7acn]]." />The bulk of citrate cycle processing happens in mitochondria and so, studies concentrated on <scene name='Aconitase/7acn-sf4/1'>the mitochondrial ACO</scene>. The <scene name='Aconitase/7acn-sf4-3cys/1'>(4Fe-4S) cofactor is held in place</scene> by three sulfur atoms belonging to the cysteins-385, -448, and -451. | ||
<!--It is clear that, in order to synthesize L-isocitrate, stereoselective catalysis must occur.--> | <!--It is clear that, in order to synthesize L-isocitrate, stereoselective catalysis must occur.--> | ||