2io6: Difference between revisions

Revision as of 08:57, 18 February 2009

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File:2io6.png

Template:STRUCTURE 2io6

Wee1 kinase complexed with inhibitor PD330961Wee1 kinase complexed with inhibitor PD330961

Template:ABSTRACT PUBMED 17869387

About this StructureAbout this Structure

2IO6 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}

↑ Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem. 2008 Jun;43(6):1276-96. Epub 2007 Aug 6. PMID:17869387 doi:10.1016/j.ejmech.2007.07.016
↑ Squire CJ, Dickson JM, Ivanovic I, Baker EN. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure. 2005 Apr;13(4):541-50. PMID:15837193 doi:10.1016/j.str.2004.12.017

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OCA

[1] Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA. Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem. 2008 Jun;43(6):1276-96. Epub 2007 Aug 6. PMID:17869387 doi:10.1016/j.ejmech.2007.07.016

[2] Squire CJ, Dickson JM, Ivanovic I, Baker EN. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure. 2005 Apr;13(4):541-50. PMID:15837193 doi:10.1016/j.str.2004.12.017

[xtra 1]

[xtra 2]

@@ Line 20: / Line 20: @@
 ==About this Structure==
-IO6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO6 OCA].
+IO6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO6 OCA].
 ==Reference==
-Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases., Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA, Eur J Med Chem. 2007 Aug 6;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17869387 17869387]
+<ref group="xtra">PMID:17869387</ref><ref group="xtra">PMID:15837193</ref><references group="xtra"/>
-Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation., Squire CJ, Dickson JM, Ivanovic I, Baker EN, Structure. 2005 Apr;13(4):541-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837193 15837193]
 [[Category: Homo sapiens]]
 [[Category: Non-specific protein-tyrosine kinase]]
-[[Category: Single protein]]
 [[Category: Baker, E N.]]
 [[Category: Dickson, J M.]]
@@ Line 36: / Line 33: @@
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:23:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:57:05 2009''