2p4j: Difference between revisions

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==About this Structure==
==About this Structure==
2P4J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4J OCA].  
2P4J is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4J OCA].  


==Reference==
==Reference==
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands., Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J, J Med Chem. 2007 May 17;50(10):2399-407. Epub 2007 Apr 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17432843 17432843]
<ref group="xtra">PMID:17432843</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
[[Category: Single protein]]
[[Category: Ghosh, A K.]]
[[Category: Ghosh, A K.]]
[[Category: Hong, L.]]
[[Category: Hong, L.]]
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[[Category: Structure based drug design]]
[[Category: Structure based drug design]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:25:56 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:06:40 2009''

Revision as of 15:06, 17 February 2009

File:2p4j.png

Template:STRUCTURE 2p4j

Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3

Template:ABSTRACT PUBMED 17432843

About this StructureAbout this Structure

2P4J is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407. Epub 2007 Apr 14. PMID:17432843 doi:10.1021/jm061338s

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