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[[Image:1dan.gif|left|100px]] | |||
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==Overview== | ==Overview== | ||
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation. | Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation. | ||
[[Category: Banner DW]] | |||
[[Category: Chene C]] | |||
[[Category: D'Arcy A]] | |||
[[Category: Guha A]] | |||
[[Category: Kirchhofer D]] | |||
[[Category: Konigsberg WH]] | |||
[[Category: Nemerson Y]] | |||
[[Category: Winkler FK]] | |||
''Page seeded by [http://bip.weizmann.ac.il/oca OCA ] on Thu Oct 25 | ''Page seeded by [http://bip.weizmann.ac.il/oca OCA ] on Thu Oct 25 11:09:10 2007'' | ||
Revision as of 12:04, 25 October 2007
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OverviewOverview
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
Page seeded by OCA on Thu Oct 25 11:09:10 2007