1hsg: Difference between revisions

Revision as of 13:56, 17 February 2009

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File:1hsg.png

1hsg, resolution 2.00Å ()

Ligands:

Gene:

HIV-1 PROTEASE FROM THE NY5 ISOLATE (Human immunodeficiency virus 1)

Structural annotation:
Resources:	CATH : 1Hsga00, 1Hsgb00 InterPro : Ipr010659, Ipr010999, Ipr001995, Ipr008916, Ipr010661, Ipr002156, Ipr001878, Ipr000071, Ipr000721, Ipr012337, Ipr001037, Ipr009007, Ipr001969, Ipr008919, Ipr003308, Ipr000477, Ipr013084, Ipr001584 Pfam : PF00077 SCOP : d1hsga_, d1hsgb_ UniProt : P03367

Functional annotation:
Cellular component:	cytoplasm viral nucleocapsid nucleus membrane viral capsid virion
Biological process:	viral reproduction viral procapsid maturation DNA integration proteolysis DNA recombination RNA-dependent DNA replication transposition, DNA-mediated
Molecular function:	hydrolase activity nucleotidyltransferase activity ribonuclease H activity nucleic acid binding aspartic-type endopeptidase activity peptidase activity endonuclease activity DNA binding transferase activity RNA-directed DNA polymerase activity metal ion binding structural molecule activity RNA binding magnesium ion binding DNA-directed DNA polymerase activity zinc ion binding nuclease activity catalytic activity integrase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASESCRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Template:ABSTRACT PUBMED 7929352

About this StructureAbout this Structure

1HSG is a 2 chains structure of sequences from Human immunodeficiency virus 1. The June 2000 RCSB PDB Molecule of the Month feature on HIV-1 Protease by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_6. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J Biol Chem. 1994 Oct 21;269(42):26344-8. PMID:7929352

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[1] Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J Biol Chem. 1994 Oct 21;269(42):26344-8. PMID:7929352

[xtra 1]

@@ Line 20: / Line 20: @@
 ==About this Structure==
-HSG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Additional information on 1HSG is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb6_1.html HIV-1 Protease] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSG OCA].
+HSG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. The June 2000 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''HIV-1 Protease''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2000_6 10.2210/rcsb_pdb/mom_2000_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSG OCA].
 ==Reference==
-Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases., Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC, J Biol Chem. 1994 Oct 21;269(42):26344-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7929352 7929352]
+<ref group="xtra">PMID:7929352</ref><references group="xtra"/>
 [[Category: HIV-1 Protease]]
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Single protein]]
 [[Category: Chen, Z.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:48:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:56:09 2009''