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| ==About this Structure== | | ==About this Structure== |
| 2ORS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORS OCA]. | | 2ORS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORS OCA]. |
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| ==Reference== | | ==Reference== |
| Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors., Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G, J Med Chem. 2007 Mar 22;50(6):1146-57. Epub 2007 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17315988 17315988]
| | <ref group="xtra">PMID:17315988</ref><ref group="xtra">PMID:17336523</ref><ref group="xtra">PMID:10677491</ref><ref group="xtra">PMID:9334294</ref><ref group="xtra">PMID:9271491</ref><references group="xtra"/> |
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| The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase., Whitlow M, Adler M, Davey D, Huang Q, Koovakkat S, Parkinson JF, Pham E, Polokoff M, Xu W, Yuan S, Phillips G, Bioorg Med Chem Lett. 2007 May 1;17(9):2505-8. Epub 2007 Feb 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17336523 17336523]
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| Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry., McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ, Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1506-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10677491 10677491]
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| The structure of nitric oxide synthase oxygenase domain and inhibitor complexes., Crane BR, Arvai AS, Gachhui R, Wu C, Ghosh DK, Getzoff ED, Stuehr DJ, Tainer JA, Science. 1997 Oct 17;278(5337):425-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334294 9334294]
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| Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction., Ghosh DK, Wu C, Pitters E, Moloney M, Werner ER, Mayer B, Stuehr DJ, Biochemistry. 1997 Sep 2;36(35):10609-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9271491 9271491]
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| [[Category: Mus musculus]] | | [[Category: Mus musculus]] |
| [[Category: Nitric-oxide synthase]] | | [[Category: Nitric-oxide synthase]] |
| [[Category: Single protein]]
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| [[Category: Adler, M.]] | | [[Category: Adler, M.]] |
| [[Category: Whitlow, M.]] | | [[Category: Whitlow, M.]] |
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| [[Category: No]] | | [[Category: No]] |
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:51:06 2008'' | | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:39:18 2009'' |