2zyb: Difference between revisions

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New page: '''Unreleased structure''' The entry 2zyb is ON HOLD Authors: Ozawa, T., Tsuji, E., Mukaiyama, T., Nishimura, T., Kobayashi, S., Ozawa, M., Okazaki, K., Kitaura, K. Description: Crysta...
 
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'''Unreleased structure'''
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[[Image:2zyb.jpg|left|200px]]


The entry 2zyb is ON HOLD
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Authors: Ozawa, T., Tsuji, E., Mukaiyama, T., Nishimura, T., Kobayashi, S., Ozawa, M., Okazaki, K., Kitaura, K.
===Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)===


Description: Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  4 11:11:18 2009''
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{{ABSTRACT_PUBMED_18977146}}
 
==Disease==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
 
==About this Structure==
2ZYB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYB OCA].
 
==Reference==
<ref group="xtra">PMID:18977146</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Tsuji, E.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Cell membrane]]
[[Category: Chromosomal rearrangement]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Host-virus interaction]]
[[Category: Kinase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Nucleotide-binding]]
[[Category: Palmitate]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Proto-oncogene]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Signal transduction]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  4 11:25:06 2009''

Revision as of 12:25, 4 February 2009

File:2zyb.jpg

Template:STRUCTURE 2zyb

Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Template:ABSTRACT PUBMED 18977146

DiseaseDisease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this StructureAbout this Structure

2ZYB is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase. Bioorg Med Chem. 2008 Dec 15;16(24):10311-8. Epub 2008 Oct 22. PMID:18977146 doi:10.1016/j.bmc.2008.10.041

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