Conservation, Evolutionary: Difference between revisions
Eric Martz (talk | contribs) added consurfDB |
Eric Martz (talk | contribs) →Locating Conserved Patches: added links to examples |
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Patches of highly conserved residues on the surface of a protein molecular structure are good candidates for [[Site | functional sites]]. These can be readily identified and visualized automatically with the [http://consurf.tau.ac.il ConSurf Server], provided a sufficient number of related protein sequences are in the Uniprot database. Before submitting a custom job request to the [http://consurf.tau.ac.il ConSurf Server], check out your [[PDB code]] at [http://consurfdb.tau.ac.il ConSurfDB], a database of precalculated conservation levels for most chains in the [[Protein Data Bank]]. | Patches of highly conserved residues on the surface of a protein molecular structure are good candidates for [[Site | functional sites]]. These can be readily identified and visualized automatically with the [http://consurf.tau.ac.il ConSurf Server], provided a sufficient number of related protein sequences are in the Uniprot database. Before submitting a custom job request to the [http://consurf.tau.ac.il ConSurf Server], check out your [[PDB code]] at [http://consurfdb.tau.ac.il ConSurfDB], a database of precalculated conservation levels for most chains in the [[Protein Data Bank]]. | ||
Examples of conserved patches revealed by ConSurf will be found in the articles on | |||
*[[Lac repressor]] | |||
*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]] | |||
==Locating Variable Patches== | ==Locating Variable Patches== | ||