3byu: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Seed}} | {{Seed}} | ||
[[Image:3byu. | [[Image:3byu.png|left|200px]] | ||
<!-- | <!-- | ||
| Line 12: | Line 12: | ||
===co-crystal structure of Lck and aminopyrimidine reverse amide 23=== | ===co-crystal structure of Lck and aminopyrimidine reverse amide 23=== | ||
<!-- | |||
The line below this paragraph, {{ABSTRACT_PUBMED_18321037}}, adds the Publication Abstract to the page | |||
(as it appears on PubMed at http://www.pubmed.gov), where 18321037 is the PubMed ID number. | |||
--> | |||
{{ABSTRACT_PUBMED_18321037}} | |||
==Disease== | ==Disease== | ||
| Line 17: | Line 23: | ||
==About this Structure== | ==About this Structure== | ||
3BYU is a | 3BYU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYU OCA]. | ||
==Reference== | |||
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18321037 18321037] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Huang, X.]] | [[Category: Huang, X.]] | ||
[[Category: Alternative splicing]] | [[Category: Alternative splicing]] | ||
| Line 42: | Line 50: | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 09:11:13 2008'' | ||
Revision as of 10:11, 31 December 2008
co-crystal structure of Lck and aminopyrimidine reverse amide 23co-crystal structure of Lck and aminopyrimidine reverse amide 23
Template:ABSTRACT PUBMED 18321037
DiseaseDisease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this StructureAbout this Structure
3BYU is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037
Page seeded by OCA on Wed Dec 31 09:11:13 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Huang, X.
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Cytoplasm
- Disease mutation
- Host-virus interaction
- Kinase domain
- Lck
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase