User:Tom Gluick/glutamine synthetase/Assignment 3: Difference between revisions
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==Glutamine Synthetase CATH Domains== | ==Glutamine Synthetase CATH Domains== | ||
<applet load='1f1h' size='400' color='white' frame='true' align='right' caption='Glutamine synthetase from Salmonella typhimurium' /> | |||
Glutamine Synthetase (GS) has 2 prominent CATH domains. CATH is an acronym for Class (C), Architecture (A), Topology (T), and Homologous superfamily (H), which are categories for protein classification. Each of the aforementioned levels are used to classify molecules in a hierarchical manner. The highest order classification of a molecule is Class. A molecule can be classified by any one of 4 classes: Mainly Alpha, Mainly Beta, Alpha Beta, and Few Secondary Structures <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. Another level of classification which is on a lower order than class is Architecture. This level of classification is used to identify the shape of the domain structure using the orientation of secondary structures but ignoring the way they are connected to each other <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. A third level of classification is Topology, which is also called Fold Group. This classification concerns the shared similarity of overall shape and connectivity of the secondary structures in the domain core <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. The Homologous superfamily refers to a fourth classification type. This hierarchy groups together protein domains which are thought to share a common ancestor, according to specific criteria <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. | Glutamine Synthetase (GS) has 2 prominent CATH domains. CATH is an acronym for Class (C), Architecture (A), Topology (T), and Homologous superfamily (H), which are categories for protein classification. Each of the aforementioned levels are used to classify molecules in a hierarchical manner. The highest order classification of a molecule is Class. A molecule can be classified by any one of 4 classes: Mainly Alpha, Mainly Beta, Alpha Beta, and Few Secondary Structures <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. Another level of classification which is on a lower order than class is Architecture. This level of classification is used to identify the shape of the domain structure using the orientation of secondary structures but ignoring the way they are connected to each other <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. A third level of classification is Topology, which is also called Fold Group. This classification concerns the shared similarity of overall shape and connectivity of the secondary structures in the domain core <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. The Homologous superfamily refers to a fourth classification type. This hierarchy groups together protein domains which are thought to share a common ancestor, according to specific criteria <ref name="rasmol"> CATH Protein Structure Classification." CATH. 03 Sep 2008. Orengo group projects. 7 Dec 2008 http://www.cathdb.info/</ref>. | ||