3ekk: Difference between revisions

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'''Unreleased structure'''
{{Seed}}
[[Image:3ekk.jpg|left|200px]]


The entry 3ekk is ON HOLD until Paper Publication
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{{STRUCTURE_3ekk|  PDB=3ekk  |  SCENE=  }}


Authors: Chamberlain, S., Atkins, C., Deanda, F., Dumble, M., Gerding, R., Groy, A., Korenchuk, S., Kumar, R., Lei, H., Mook, R., Moorthy, G., Redman, A., Rowland, J., Sabbatini, P., Shewchuk, L.
===Insulin receptor kinase complexed with an inhibitor===


Description: Insulin receptor kinase complexed with an inhibitor


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  8 09:20:04 2008''
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{{ABSTRACT_PUBMED_19056263}}
 
==Disease==
Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Leprechaunism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]], Rabson-Mendenhall syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147670 147670]]
 
==About this Structure==
3EKK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EKK OCA].
 
==Reference==
Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase., Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA Jr, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB, Bioorg Med Chem Lett. 2008 Nov 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19056263 19056263]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Atkins, C.]]
[[Category: Chamberlain, S.]]
[[Category: Deanda, F.]]
[[Category: Dumble, M.]]
[[Category: Gerding, R.]]
[[Category: Groy, A.]]
[[Category: Korenchuk, S.]]
[[Category: Kumar, R.]]
[[Category: Lei, H.]]
[[Category: Mook, R.]]
[[Category: Moorthy, G.]]
[[Category: Redman, A.]]
[[Category: Rowland, J.]]
[[Category: Sabbatini, P.]]
[[Category: Shewchuk, L.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Carbohydrate metabolism]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Diabetes mellitus]]
[[Category: Disease mutation]]
[[Category: Glycoprotein]]
[[Category: Insulin]]
[[Category: Kinase]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine-protein kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:32:29 2008''

Revision as of 12:32, 24 December 2008

File:3ekk.jpg

Template:STRUCTURE 3ekk

Insulin receptor kinase complexed with an inhibitorInsulin receptor kinase complexed with an inhibitor

Template:ABSTRACT PUBMED 19056263

DiseaseDisease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this StructureAbout this Structure

3EKK is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase., Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA Jr, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB, Bioorg Med Chem Lett. 2008 Nov 18. PMID:19056263

Page seeded by OCA on Wed Dec 24 11:32:29 2008

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