User:Tsung-Yi Lin/Sandbox: Difference between revisions
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Tsung-Yi Lin (talk | contribs) |
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*It consists 99 amino acids, which forming 10 β-strand and 1 α-helix. | *It consists 99 amino acids, which forming 10 β-strand and 1 α-helix. | ||
[[Image: | [[Image:Mechanism.jpg|350px]] | ||
'''Domains in HIV-1 protease''' | '''Domains in HIV-1 protease''' | ||
''Terminal domain or dimerization domain'' | ''Terminal domain or dimerization domain'' | ||
*Consists of the termini four-stranded beta-sheet; (residues 1-4, and 95-99 of each monomer), the turn encompassing residues 4-9, and the helix (residues 86-94 of each monomer). This domain is quite crucial in dimer formation and stabilization of an active PR. | *Consists of the termini four-stranded beta-sheet; (residues 1-4, and 95-99 of each monomer), the turn encompassing residues 4-9, and the helix (residues 86-94 of each monomer). This domain is quite crucial in dimer formation and stabilization of an active PR. | ||
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*These are two; one from each monomer. | *These are two; one from each monomer. | ||
*Composed of primarily four beta-strand structures; and is quite compact. | *Composed of primarily four beta-strand structures; and is quite compact. | ||
Residues 10-32 and 63-85 from each monomer make up the domain sequence | *Residues 10-32 and 63-85 from each monomer make up the domain sequence | ||
*The conserved Asp25-Thr26-Gly27 catalytic triad, is situated at the interface of the core domains from the two monomers. | *The conserved Asp25-Thr26-Gly27 catalytic triad, is situated at the interface of the core domains from the two monomers. | ||
*This domain is quite useful in dimer stabilization, as well as the catalytic site stability. | *This domain is quite useful in dimer stabilization, as well as the catalytic site stability. | ||
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*Flexible flaps enclose the active site and provide important ligand binding interactions. | *Flexible flaps enclose the active site and provide important ligand binding interactions. | ||
[[Image: | [[Image:Domains.png|350px]] | ||
== Reference == | == Reference == | ||