Prion protein: Difference between revisions

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Kurt Giles, Jaime Prilusky, Eran Hodis, Claudio Garutti, Michal Harel, Joel L. Sussman

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-The prion protein (PrP) is a cell surface glycoprotein. The cellular isoform (PrPC) is predominantly α-helical, but can undergo a structural conversion to a β-sheet rich conformation, termed PrPSc. Prion diseases such as Creutzfeldt Jakob disease (CJD) in people, and bovine spongiform encephalopathy (BSE) commonly known as "mad cow" disease, are characterterized by aggregates of PrPSc
+The prion protein (PrP) is a cell surface glycoprotein. The cellular isoform (PrP<sup>C</sup>) is predominantly α-helical, but can undergo a structural conversion to a β-sheet rich conformation, termed PrP<sup>Sc</sup>. Prion diseases such as Creutzfeldt Jakob disease (CJD) in people, and bovine spongiform encephalopathy (BSE) commonly known as "mad cow" disease, are characterterized by aggregates of PrP<sup>Sc</sup>, which arise from autocatalytic refolding of PrP<sup>C</sup> in a template-dependent manner.
+Structure from  a
     's normal cellular function is debated, and "knockout" mice lacking PrP are phenotypically normal.
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 {{STRUCTURE_1hjm |  PDB=1hjm  |  SCENE=  }}
+==PrP structures==
+AG2 Mouse PrP 121-231 determined by NMR
+B10 Syrian hamster PrP 90-231 NMR ensemble of 25 structures
+DWY BoPrP               121-230 Average            124-227
+DWZ BoPrP               121-230 20 structures      124-227
+DX0 BoPrP                23-230 Average            124-227
+DX1 BoPrP                23-230 20 structures      124-227
+E1G HuPrP,M166V         125-228 20 structures      125-228
+E1J HuPrP,M166V         125-228 Average            125-228
+E1P HuPrP,S170N         125-228 20 structures      125-228
+E1S HuPrP,S170N         125-228 Average            125-228
+E1U HuPrP,R220K         125-228 20 structures      125-228
+E1W HuPrP,R220K         125-228 Average            125-228
+FKC HuPrP,E200K          90-231 Average            125-231
+FO7 HuPrP,E200K          90-231 30 structures      125-231
+HJM HuPrP                       Average
+HJN HuPrP                       20 structures
+H0L HuPrP,M166C,E221C   121-230 20 structures      119-230
+I4M HuPrP               119-226 (X-ray)            119-226
+QLX HuPrP                23-230 Average            125-228
+QLZ HuPrP                23-230 20 structures      125-228
+QM0 HuPrP                90-230 Average            125-228
+QM1 HuPrP                90-230 20 structures      125-228
+QM2 HuPrP               121-230 Average            125-228
+QM3 HuPrP               121-230 20 structures      125-228
+UW3 OvPrP