Transcription Termination Factor Rho: Difference between revisions
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'''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific | '''Transcription termination factor Rho''' is a ring-shaped RNA-DNA '''helicase''' that induces release of transcription complexes at specific loci of bacterial genomes. Several structures of Rho in various liganded states haven been solved by X-ray crystallography by the J. M. Berger lab (Berkeley): [[1a8v]], [[1pv4]], [[1pvo]], [[1xpr]], [[1xpu]], [[2a8v]], and [[2ht1]]. | ||
The [[Asymmetric Unit|asymmetric unit]] solved as [[2ht1]] contains only two chains, so it represents only one third of the [[Biological unit]], which is a homo-hexamer. | |||
Here is one representation showing the <scene name='Transcription_Termination_Factor_Rho/Rho_closed_1/3'>Rho hexamer in a closed state</scene>Rho hexamer in a closed state and with RNA fragments occupying both its primary and secondary binding sites. | |||
<applet load='Rho1.pdb' size='300' frame='true' align='right' scene='Transcription_Termination_Factor_Rho/Rho_closed_1/3'> | <applet load='Rho1.pdb' size='300' frame='true' align='right' scene='Transcription_Termination_Factor_Rho/Rho_closed_1/3'> |