3eqb: Difference between revisions

Revision as of 11:50, 12 November 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3eqb.jpg

Template:STRUCTURE 3eqb

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATPX-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Template:ABSTRACT PUBMED 18951019

About this StructureAbout this Structure

3EQB is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)., Warmus JS, Flamme C, Zhang LY, Barrett S, Bridges A, Chen H, Gowan R, Kaufman M, Sebolt-Leopold J, Leopold W, Merriman R, Ohren J, Pavlovsky A, Przybranowski S, Tecle H, Valik H, Whitehead C, Zhang E, Bioorg Med Chem Lett. 2008 Oct 7. PMID:18951019

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase., Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H, J Med Chem. 2007 Oct 18;50(21):5090-102. Epub 2007 Sep 19. PMID:17880056

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition., Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA, Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:15543157

Page seeded by OCA on Wed Nov 12 10:50:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
+[[Image:3eqb.jpg|left|200px]]
-The entry 3eqb is ON HOLD
+<!--
+The line below this paragraph, containing "STRUCTURE_3eqb", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_3eqb|  PDB=3eqb  |  SCENE=  }}
-Authors: Ohren, J.F., Pavlovsky, A., Zhang, E.
+===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP===
-Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 14:06:26 2008''
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_18951019}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18951019 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18951019}}
+==About this Structure==
+EQB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQB OCA].
+==Reference==
+-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)., Warmus JS, Flamme C, Zhang LY, Barrett S, Bridges A, Chen H, Gowan R, Kaufman M, Sebolt-Leopold J, Leopold W, Merriman R, Ohren J, Pavlovsky A, Przybranowski S, Tecle H, Valik H, Whitehead C, Zhang E, Bioorg Med Chem Lett. 2008 Oct 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18951019 18951019]
+-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase., Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H, J Med Chem. 2007 Oct 18;50(21):5090-102. Epub 2007 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17880056 17880056]
+Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition., Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA, Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. Epub 2004 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15543157 15543157]
+[[Category: Homo sapiens]]
+[[Category: Mitogen-activated protein kinase kinase]]
+[[Category: Ohren, J F.]]
+[[Category: Pavlovsky, A.]]
+[[Category: Zhang, E.]]
+[[Category: Acetylation]]
+[[Category: Atp-binding]]
+[[Category: Disease mutation]]
+[[Category: Kinase]]
+[[Category: Ligand and mgatp]]
+[[Category: Ligand co-complex]]
+[[Category: Mitogen activated protein kinase kinase]]
+[[Category: Non-competitive protein kinase inhibitor]]
+[[Category: Nucleotide-binding]]
+[[Category: Phosphoprotein]]
+[[Category: Protein kinase structure]]
+[[Category: Serine/threonine-protein kinase]]
+[[Category: Signal transduction]]
+[[Category: Ternary co-complex with kinase]]
+[[Category: Transferase]]
+[[Category: Tyrosine-protein kinase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 10:50:02 2008''