Lac repressor: Difference between revisions
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<big><b>To Be Continued ....</b></big> [[User:Eric Martz|Eric Martz]] 16:22, 14 October 2008 (IST) | <big><b>To Be Continued ....</b></big> [[User:Eric Martz|Eric Martz]] 16:22, 14 October 2008 (IST) | ||
==DNA Binding: Bending the Operator== | |||
<applet load='Insert PDB code or filename here' size='400' frame='true' align='right' caption='Insert caption here' /> | |||
Lac repressor binds to DNA non-specifically, enabling it to slide rapidly along the DNA double helix until it encounters the lac operator sequence. Upon recognizing the specific operator sequence, the binding converts from non-specific to specific. During this conversion, the hinge region goes from a disordered loop to an alpha helix, which binds in the minor groove of the DNA. This binding opens the minor groove, bending the DNA. | |||
Forming sequence-specific hydrogen bonds with DNA bases. | |||
==References== | ==References== | ||
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