Pyruvate phosphate dikinase: Difference between revisions
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Pyruvate phosphate dikinase (PPDK) catalyzes the inter-conversion of adenosine triphosphate (ATP), P<sub>i</sub>, and pyruvate with adenine monophosphate (AMP), pyrophosphate (PP<sub>i</sub>, and phosphoenolpyruvate (PEP) in the presence of Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>. The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | Pyruvate phosphate dikinase (PPDK) catalyzes the inter-conversion of adenosine triphosphate (ATP), P<sub>i</sub>, and pyruvate with adenine monophosphate (AMP), pyrophosphate (PP<sub>i</sub>, and phosphoenolpyruvate (PEP) in the presence of Mg<sup>2+</sup> and K<sup>+</sup>/Na<sup>+</sup>. The three-step reversible reaction proceeds via phosphoenzyme and pyrophosphoenzyme intermediates with a histidine residue serving as the phosphocarrier: | ||
1. PPDK-His + PEP ⇄ PPDK-His~PO3 + pyruvate | 1. PPDK-His + PEP ⇄ PPDK-His~PO3 + pyruvate | ||