2dln: Difference between revisions

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-[[Image:2dln.jpg|left|200px]]
+{{Seed}}
+[[Image:2dln.png|left|200px]]
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 {{STRUCTURE_2dln|  PDB=2dln  |  SCENE=  }}
-'''VANCOMYCIN RESISTANCE: STRUCTURE OF D-ALANINE:D-ALANINE LIGASE AT 2.3 ANGSTROMS RESOLUTION'''
+===VANCOMYCIN RESISTANCE: STRUCTURE OF D-ALANINE:D-ALANINE LIGASE AT 2.3 ANGSTROMS RESOLUTION===
-==Overview==
+<!--
-The molecular structure of the D-alanine:D-alanine ligase of the ddlB gene of Escherichia coli, co-crystallized with an S,R-methylphosphinate and adenosine triphosphate, was determined by x-ray diffraction to a resolution of 2.3 angstroms. A catalytic mechanism for the ligation of two D-alanine substrates is proposed in which a helix dipole and a hydrogen-bonded triad of tyrosine, serine, and glutamic acid assist binding and deprotonation steps. From sequence comparison, it is proposed that a different triad exists in a recently discovered D-alanine:D-lactate ligase (VanA) present in vancomycin-resistant enterococci. A molecular mechanism for the altered specificity of VanA is suggested.
+The line below this paragraph, {{ABSTRACT_PUBMED_7939684}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7939684 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7939684}}
 ==About this Structure==
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 [[Category: Knox, J R.]]
 [[Category: Moews, P C.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:41:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:53:59 2008''