2pvk: Difference between revisions

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{{STRUCTURE_2pvk|  PDB=2pvk  |  SCENE=  }}  
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'''Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2'''
===Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2===




==Overview==
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The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with microM-level cytotoxic activity in cell-based assays with prostate and colon cancer cell lines.
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==About this Structure==
==About this Structure==
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[[Category: Structure-based drug design]]
[[Category: Structure-based drug design]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 15:42, 29 July 2008

File:2pvk.png

Template:STRUCTURE 2pvk

Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2Structure-Based Design of Pyrazolo[1,5-a][1,3,5]triazine Derivatives as Potent Inhibitors of Protein Kinase CK2

Template:ABSTRACT PUBMED 17540560

About this StructureAbout this Structure

2PVK is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

ReferenceReference

Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2., Nie Z, Perretta C, Erickson P, Margosiak S, Almassy R, Lu J, Averill A, Yager KM, Chu S, Bioorg Med Chem Lett. 2007 Aug 1;17(15):4191-5. Epub 2007 May 18. PMID:17540560

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