1s78: Difference between revisions

Revision as of 15:14, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1s78.png

Template:STRUCTURE 1s78

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexInsights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Template:ABSTRACT PUBMED 15093539

About this StructureAbout this Structure

1S78 is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex., Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX, Cancer Cell. 2004 Apr;5(4):317-28. PMID:15093539

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab., Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ, Nature. 2003 Feb 13;421(6924):756-60. PMID:12610629

Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis., Vajdos FF, Adams CW, Breece TN, Presta LG, de Vos AM, Sidhu SS, J Mol Biol. 2002 Jul 5;320(2):415-28. PMID:12079396

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth., Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, Sliwkowski MX, Cancer Cell. 2002 Aug;2(2):127-37. PMID:12204533

Page seeded by OCA on Tue Jul 29 15:14:41 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1s78.jpg|left|200px]]
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 {{STRUCTURE_1s78|  PDB=1s78  |  SCENE=  }}
-'''Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex'''
+===Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex===
-==Overview==
+<!--
-We have determined the 3.2 A X-ray crystal structure of the extracellular domain of the human epidermal growth factor receptor 2 (ErbB2 or HER2) in a complex with the antigen binding fragment of pertuzumab, an anti-ErbB2 monoclonal antibody also known as 2C4 or Omnitarg. Pertuzumab binds to ErbB2 near the center of domain II, sterically blocking a binding pocket necessary for receptor dimerization and signaling. The ErbB2-pertuzumab structure, combined with earlier mutagenesis data, defines the pertuzumab residues essential for ErbB2 interaction. To analyze the ErbB2 side of the interface, we have mutated a number of residues contacting pertuzumab and examined the effects of these mutations on pertuzumab binding and ErbB2-ErbB3 heterodimerization. We have also shown that conserved residues previously shown to be necessary for EGF receptor homodimerization may be dispensible for ErbB2-ErbB3 heterodimerization.
+The line below this paragraph, {{ABSTRACT_PUBMED_15093539}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15093539 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15093539}}
 ==About this Structure==
@@ Line 20: / Line 24: @@
 ==Reference==
 Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex., Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX, Cancer Cell. 2004 Apr;5(4):317-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15093539 15093539]
+Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab., Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ, Nature. 2003 Feb 13;421(6924):756-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12610629 12610629]
+Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis., Vajdos FF, Adams CW, Breece TN, Presta LG, de Vos AM, Sidhu SS, J Mol Biol. 2002 Jul 5;320(2):415-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12079396 12079396]
+Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth., Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, Sliwkowski MX, Cancer Cell. 2002 Aug;2(2):127-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12204533 12204533]
 [[Category: Homo sapiens]]
 [[Category: Mus musculus]]
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 [[Category: Leucine-rich repeat]]
 [[Category: Receptor-antibody complex]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:14:41 2008''