2z4f: Difference between revisions

Revision as of 14:33, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2z4f.png

Template:STRUCTURE 2z4f

Solution structure of the Discoidin Domain of DDR2Solution structure of the Discoidin Domain of DDR2

Template:ABSTRACT PUBMED 17703188

About this StructureAbout this Structure

2Z4F is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

ReferenceReference

Structural basis of the collagen-binding mode of discoidin domain receptor 2., Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I, EMBO J. 2007 Sep 19;26(18):4168-76. Epub 2007 Aug 16. PMID:17703188

Page seeded by OCA on Tue Jul 29 14:33:14 2008

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OCA

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-[[Image:2z4f.gif|left|200px]]
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 {{STRUCTURE_2z4f|  PDB=2z4f  |  SCENE=  }}
-'''Solution structure of the Discoidin Domain of DDR2'''
+===Solution structure of the Discoidin Domain of DDR2===
-==Overview==
+<!--
-Discoidin domain receptor (DDR) is a cell-surface receptor tyrosine kinase activated by the binding of its discoidin (DS) domain to fibrillar collagen. Here, we have determined the NMR structure of the DS domain in DDR2 (DDR2-DS domain), and identified the binding site to fibrillar collagen by transferred cross-saturation experiments. The DDR2-DS domain structure adopts a distorted jellyroll fold, consisting of eight beta-strands. The collagen-binding site is formed at the interloop trench, consisting of charged residues surrounded by hydrophobic residues. The surface profile of the collagen-binding site suggests that the DDR2-DS domain recognizes specific sites on fibrillar collagen. This study provides a molecular basis for the collagen-binding mode of the DDR2-DS domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_17703188}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17703188 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17703188}}
 ==About this Structure==
-Z4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4F OCA].
+Z4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z4F OCA].
 ==Reference==
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 [[Category: Beta barrel]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:56:24 2008''
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