2duv: Difference between revisions

Revision as of 14:18, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2duv.png

Template:STRUCTURE 2duv

Structure of CDK2 with a 3-hydroxychromonesStructure of CDK2 with a 3-hydroxychromones

Template:ABSTRACT PUBMED 17178224

About this StructureAbout this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

Page seeded by OCA on Tue Jul 29 14:17:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-==Overview==
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-A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
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 [[Category: Protein kinase]]
 [[Category: Serine/threonine-protein kinase]]
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