2e2s: Difference between revisions

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-[[Image:2e2s.jpg|left|200px]]
+{{Seed}}
+[[Image:2e2s.png|left|200px]]
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 {{STRUCTURE_2e2s|  PDB=2e2s  |  SCENE=  }}
-'''Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta'''
+===Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta===
-==Overview==
+<!--
-Agelenin, isolated from the Agelenidae spider Agelena opulenta, is a peptide composed of 35 amino acids. We determined the three-dimensional structure of agelenin using two-dimensional NMR spectroscopy. The structure is composed of a short antiparallel beta-sheet and four beta-turns, which are stabilized by three disulfide bonds. Agelenin has characteristic residues, Phe9, Ser28 and Arg33, which are arranged similarly to the pharmacophore of the insect channel inhibitor, omega-atracotoxin-Hv1a. These observations suggest that agelenin and omega-atracotoxin-Hv1a bind to insect calcium channels in a similar manner. We also suggest that another mode of action may operate in the channel inhibition by omega-agatoxin-IVA and omega-atracotoxin-Hv2a.
+The line below this paragraph, {{ABSTRACT_PUBMED_17644092}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17644092 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17644092}}
 ==About this Structure==
-E2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA].
+E2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA].
 ==Reference==
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 [[Category: Presynaptic calcium channel inhibitor]]
 [[Category: Toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:49:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:08:38 2008''