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| {{STRUCTURE_3bl8| PDB=3bl8 | SCENE= }} | | {{STRUCTURE_3bl8| PDB=3bl8 | SCENE= }} |
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| '''Crystal structure of the extracellular domain of neuroligin-2A from mouse'''
| | ===Crystal structure of the extracellular domain of neuroligin-2A from mouse=== |
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| ==Overview==
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| Neuroligins (NLs) are catalytically inactive members of a family of cholinesterase-like transmembrane proteins that mediate cell adhesion at neuronal synapses. Postsynaptic neuroligins engage in Ca2+-dependent transsynaptic interactions via their extracellular cholinesterase domain with presynaptic neurexins (NRXs). These interactions may be regulated by two short splice insertions (termed A and B) in the NL cholinesterase domain. Here, we present the 3.3-A crystal structure of the ectodomain from NL2 containing splice insertion A (NL2A). The overall structure of NL2A resembles that of cholinesterases, but several structural features are unique to the NL proteins. First, structural elements surrounding the esterase active-site region differ significantly between active esterases and NL2A. On the opposite surface of the NL2A molecule, the positions of the A and B splice insertions identify a candidate NRX interaction site of the NL protein. Finally, sequence comparisons of NL isoforms allow for mapping the location of residues of previously identified mutations in NL3 and NL4 found in patients with autism spectrum disorders. Overall, the NL2 structure promises to provide a valuable model for dissecting NL isoform- and synapse-specific functions.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18250328}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18250328 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18250328}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Phosphoprotein]] | | [[Category: Phosphoprotein]] |
| [[Category: Transmembrane]] | | [[Category: Transmembrane]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:53:53 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:58:32 2008'' |