2jmz: Difference between revisions

Revision as of 13:51, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2jmz.png

Template:STRUCTURE 2jmz

Solution structure of a KlbA intein precursor from Methanococcus jannaschiiSolution structure of a KlbA intein precursor from Methanococcus jannaschii

Template:ABSTRACT PUBMED 17586768

About this StructureAbout this Structure

2JMZ is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full experimental information is available from OCA.

ReferenceReference

NMR structure of a KlbA intein precursor from Methanococcus jannaschii., Johnson MA, Southworth MW, Herrmann T, Brace L, Perler FB, Wuthrich K, Protein Sci. 2007 Jul;16(7):1316-28. PMID:17586768

Page seeded by OCA on Tue Jul 29 13:51:46 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2jmz.jpg|left|200px]]
+{{Seed}}
+[[Image:2jmz.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2jmz|  PDB=2jmz  |  SCENE=  }}
-'''Solution structure of a KlbA intein precursor from Methanococcus jannaschii'''
+===Solution structure of a KlbA intein precursor from Methanococcus jannaschii===
-==Overview==
+<!--
-Certain proteins of unicellular organisms are translated as precursor polypeptides containing inteins (intervening proteins), which are domains capable of performing protein splicing. These domains, in conjunction with a single residue following the intein, catalyze their own excision from the surrounding protein (extein) in a multistep reaction involving the cleavage of two intein-extein peptide bonds and the formation of a new peptide bond that ligates the two exteins to yield the mature protein. We report here the solution NMR structure of a 186-residue precursor of the KlbA intein from Methanococcus jannaschii, comprising the intein together with N- and C-extein segments of 7 and 11 residues, respectively. The intein is shown to adopt a single, well-defined globular domain, representing a HINT (Hedgehog/Intein)-type topology. Fourteen beta-strands are arranged in a complex fold that includes four beta-hairpins and an antiparallel beta-ribbon, and there is one alpha-helix, which is packed against the beta-ribbon, and one turn of 3(10)-helix in the loop between the beta-strands 8 and 9. The two extein segments show increased disorder, and form only minimal nonbonding contacts with the intein domain. Structure-based mutation experiments resulted in a proposal for functional roles of individual residues in the intein catalytic mechanism.
+The line below this paragraph, {{ABSTRACT_PUBMED_17586768}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17586768 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17586768}}
 ==About this Structure==
-JMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMZ OCA].
+JMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMZ OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: Wuthrich, K A.]]
 [[Category: Protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:03:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:51:46 2008''