1txo: Difference between revisions

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-[[Image:1txo.gif|left|200px]]
+{{Seed}}
+[[Image:1txo.png|left|200px]]
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 {{STRUCTURE_1txo|  PDB=1txo  |  SCENE=  }}
-'''Crystal structure of the Mycobacterium tuberculosis serine/threonine phosphatase PstP/Ppp at 1.95 A.'''
+===Crystal structure of the Mycobacterium tuberculosis serine/threonine phosphatase PstP/Ppp at 1.95 A.===
-==Overview==
+<!--
-Serine/threonine protein phosphatases are central mediators of phosphorylation-dependent signals in eukaryotes and a variety of pathogenic bacteria. Here, we report the crystal structure of the intracellular catalytic domain of Mycobacterium tuberculosis PstPpp, a membrane-anchored phosphatase in the PP2C family. Despite sharing the fold and two-metal center of human PP2Calpha, the PstPpp catalytic domain binds a third Mn(2+) in a site created by a large shift in a previously unrecognized flap subdomain adjacent to the active site. Mutations in this site selectively increased the Michaelis constant for Mn(2+) in the reaction of a noncognate, small-molecule substrate, p-nitrophenyl phosphate. The PstP/Ppp structure reveals core functional motifs that advance the framework for understanding the mechanisms of substrate recognition, catalysis, and regulation of PP2C phosphatases.
+The line below this paragraph, {{ABSTRACT_PUBMED_15530359}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15530359 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15530359}}
 ==About this Structure==
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 [[Category: Tb structural genomics consortium]]
 [[Category: Tbsgc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:29:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:48:09 2008''