2exs: Difference between revisions

Revision as of 13:25, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2exs.png

Template:STRUCTURE 2exs

TRAP3 (engineered TRAP)TRAP3 (engineered TRAP)

Template:ABSTRACT PUBMED 16698553

About this StructureAbout this Structure

2EXS is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

ReferenceReference

Rounding up: Engineering 12-membered rings from the cyclic 11-mer TRAP., Heddle JG, Yokoyama T, Yamashita I, Park SY, Tame JR, Structure. 2006 May;14(5):925-33. PMID:16698553

Page seeded by OCA on Tue Jul 29 13:25:34 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''TRAP3 (engineered TRAP)'''
+===TRAP3 (engineered TRAP)===
-==Overview==
+<!--
-The protein TRAP (trp RNA binding attenuation protein) forms a highly thermostable ring-shaped 11-mer. By linking in tandem two, three, or four DNA sequences encoding TRAP monomers, we have engineered new rings that consist of 12 TRAP subunits and bind 12 ligand molecules. The hydrogen bonding pattern and buried surface area within and between subunits are essentially identical between the 11-mer and 12-mer crystal structures. Why do the artificial proteins choose to make single 12-mer rings? The 12-mer rings are highly sterically strained by their peptide linkers and far from thermostable. That proteins choose to adopt a strained conformation of few subunits rather than an unstrained one with 11 subunits demonstrates the importance of entropic factors in controlling protein-protein interactions in general.
+The line below this paragraph, {{ABSTRACT_PUBMED_16698553}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_16698553}}
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 [[Category: Engineered]]
 [[Category: Ring protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:14:07 2008''
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