365d: Difference between revisions

Revision as of 13:25, 29 July 2008

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File:365d.png

Template:STRUCTURE 365d

STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVESTRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE

Template:ABSTRACT PUBMED 9461074

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074

Page seeded by OCA on Tue Jul 29 13:25:23 2008

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OCA

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-'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''
+===STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE===
-==Overview==
+<!--
-Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_9461074}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9461074}}
 ==About this Structure==
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 [[Category: Double helix]]
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