2qmd: Difference between revisions

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[[Image:2qmd.jpg|left|200px]]
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[[Image:2qmd.png|left|200px]]


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{{STRUCTURE_2qmd|  PDB=2qmd  |  SCENE=  }}  
{{STRUCTURE_2qmd|  PDB=2qmd  |  SCENE=  }}  


'''Structure of BACE Bound to SCH722924'''
===Structure of BACE Bound to SCH722924===




==Overview==
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Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.
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{{ABSTRACT_PUBMED_18023580}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:12:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:18:39 2008''

Revision as of 13:18, 29 July 2008

File:2qmd.png

Template:STRUCTURE 2qmd

Structure of BACE Bound to SCH722924Structure of BACE Bound to SCH722924

Template:ABSTRACT PUBMED 18023580

About this StructureAbout this Structure

2QMD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors., Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J, Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6. PMID:18023580

Page seeded by OCA on Tue Jul 29 13:18:39 2008

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