2hdc: Difference between revisions

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[[Image:2hdc.gif|left|200px]]
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{{STRUCTURE_2hdc|  PDB=2hdc  |  SCENE=  }}  
{{STRUCTURE_2hdc|  PDB=2hdc  |  SCENE=  }}  


'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''
===STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX===




==Overview==
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Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.
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{{ABSTRACT_PUBMED_10369754}}


==About this Structure==
==About this Structure==
2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].  
2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].  


==Reference==
==Reference==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Winged helix protein]]
[[Category: Winged helix protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:08:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:16:11 2008''

Revision as of 13:16, 29 July 2008

File:2hdc.png

Template:STRUCTURE 2hdc

STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEXSTRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

Template:ABSTRACT PUBMED 10369754

About this StructureAbout this Structure

2HDC is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

ReferenceReference

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754

Page seeded by OCA on Tue Jul 29 13:16:11 2008

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