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| [[Image:1psj.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1psj| PDB=1psj | SCENE= }} | | {{STRUCTURE_1psj| PDB=1psj | SCENE= }} |
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| '''ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS'''
| | ===ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS=== |
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| ==Overview==
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| The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed. | | The line below this paragraph, {{ABSTRACT_PUBMED_8636969}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8636969 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8636969}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Hydrolase]] | | [[Category: Hydrolase]] |
| [[Category: Lipid degradation]] | | [[Category: Lipid degradation]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:26:19 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:58:11 2008'' |