2cfp: Difference between revisions

Revision as of 12:53, 29 July 2008

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File:2cfp.png

Template:STRUCTURE 2cfp

SUGAR FREE LACTOSE PERMEASE AT ACIDIC PHSUGAR FREE LACTOSE PERMEASE AT ACIDIC PH

Template:ABSTRACT PUBMED 16525509

About this StructureAbout this Structure

2CFP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY., Mirza O, Guan L, Verner G, Iwata S, Kaback HR, EMBO J. 2006 Mar 22;25(6):1177-83. Epub 2006 Mar 9. PMID:16525509

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''SUGAR FREE LACTOSE PERMEASE AT ACIDIC PH'''
+===SUGAR FREE LACTOSE PERMEASE AT ACIDIC PH===
-==Overview==
+<!--
-Cation-coupled active transport is an essential cellular process found ubiquitously in all living organisms. Here, we present two novel ligand-free X-ray structures of the lactose permease (LacY) of Escherichia coli determined at acidic and neutral pH, and propose a model for the mechanism of coupling between lactose and H+ translocation. No sugar-binding site is observed in the absence of ligand, and deprotonation of the key residue Glu269 is associated with ligand binding. Thus, substrate induces formation of the sugar-binding site, as well as the initial step in H+ transduction.
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 ==About this Structure==
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 [[Category: Transmembrane]]
 [[Category: Transport mechanism]]
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