2cej: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-[[Image:2cej.gif|left|200px]]
+{{Seed}}
+[[Image:2cej.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2cej|  PDB=2cej  |  SCENE=  }}
-'''P1' EXTENDED HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL IN THE TRANSITION-STATE MIMICKING SCAFFOLD'''
+===P1' EXTENDED HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL IN THE TRANSITION-STATE MIMICKING SCAFFOLD===
-==Overview==
+<!--
-Two series of P1'-extended HIV-1 protease inhibitors comprising a tertiary alcohol in the transition-state mimic exhibiting Ki values ranging from 2.1 to 93 nM have been synthesized. Microwave-accelerated palladium-catalyzed cross-couplings were utilized to rapidly optimize the P1' side chain. High cellular antiviral potencies were encountered when the P1' benzyl group was elongated with a 3- or 4-pyridyl substituent (EC50 = 0.18-0.22 microM). X-ray crystallographic data were obtained for three inhibitors cocrystallized with the enzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_16509598}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16509598 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16509598}}
 ==About this Structure==
@@ Line 36: / Line 40: @@
 [[Category: Inhibitor]]
 [[Category: Protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:56:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:44:24 2008''