2d3t: Difference between revisions

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-[[Image:2d3t.gif|left|200px]]
+{{Seed}}
+[[Image:2d3t.png|left|200px]]
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 {{STRUCTURE_2d3t|  PDB=2d3t  |  SCENE=  }}
-'''Fatty Acid beta-oxidation multienzyme complex from Pseudomonas Fragi, Form V'''
+===Fatty Acid beta-oxidation multienzyme complex from Pseudomonas Fragi, Form V===
-==Overview==
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-The quaternary structure of a fatty acid beta-oxidation multienzyme complex, catalyzing three sequential reactions, was investigated by X-ray crystallographic and small-angle X-ray solution scattering analyses. X-ray crystallography revealed an intermediate structure of the complex among the previously reported structures. However, the theoretical scattering curves calculated from the crystal structures remarkably disagree with the experimental profiles. Instead, an ensemble of the atomic models, which were all calculated by rigid-body optimization, reasonably explained the experimental data. These structures significantly differ from those in the crystals, but they maintain the substrate binding pocket at the domain boundary. Comparisons among these structures indicated that binding of 3-hydroxyhexadecanoyl-CoA or nicotinamide adenine dinucleotide induces domain rearrangements in the complex. The conformational changes suggest the structural events occurring during the chain reaction catalyzed by the multienzyme complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_16472743}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16472743 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16472743}}
 ==About this Structure==
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 ==Reference==
 Ligand-induced domain rearrangement of fatty acid beta-oxidation multienzyme complex., Tsuchiya D, Shimizu N, Ishikawa M, Suzuki Y, Morikawa K, Structure. 2006 Feb;14(2):237-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472743 16472743]
+Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex., Ishikawa M, Tsuchiya D, Oyama T, Tsunaka Y, Morikawa K, EMBO J. 2004 Jul 21;23(14):2745-54. Epub 2004 Jul 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229654 15229654]
 [[Category: Acetyl-CoA C-acyltransferase]]
 [[Category: Protein complex]]
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 [[Category: Tsuchiya, D.]]
 [[Category: Alpha2beta2 heterotetrameric complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:39:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:40:58 2008''