1poc: Difference between revisions

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{{STRUCTURE_1poc|  PDB=1poc  |  SCENE=  }}  
{{STRUCTURE_1poc|  PDB=1poc  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
===CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE===




==Overview==
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The 2.0 angstroms crystal structure of a complex containing bee-venom phospholipase A2 (PLA2) and a phosphonate transition-state analogue was solved by multiple isomorphous replacement. The electron-density map is sufficiently detailed to visualize the proximal sugars of the enzyme's N-linked carbohydrate and a single molecule of the transition-state analogue bound ot its active center. Although bee-venom PLA2 does not belong to the large homologous Class I/II family that encompasses most other well-studied PLA2s, there is segmental sequence similarity and conservation of many functional substructures. Comparison of the bee-venom enzyme with other phospholipase structures provides compelling evidence for a common catalytic mechanism.
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{{ABSTRACT_PUBMED_2274788}}


==About this Structure==
==About this Structure==
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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