1z11: Difference between revisions

Revision as of 11:54, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1z11.png

Template:STRUCTURE 1z11

Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen BoundCrystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound

Template:ABSTRACT PUBMED 16086027

About this StructureAbout this Structure

1Z11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen., Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF, Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7. PMID:16086027

Page seeded by OCA on Tue Jul 29 11:54:41 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound'''
+===Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound===
-==Overview==
+<!--
-Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.
+The line below this paragraph, {{ABSTRACT_PUBMED_16086027}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16086027 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_16086027}}
 ==About this Structure==
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 [[Category: P450]]
 [[Category: P450 2a6]]
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