2i0h: Difference between revisions

Revision as of 11:44, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2i0h.png

Template:STRUCTURE 2i0h

The structure of p38alpha in complex with an arylpyridazinoneThe structure of p38alpha in complex with an arylpyridazinone

Template:ABSTRACT PUBMED 16945533

About this StructureAbout this Structure

2I0H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design., Natarajan SR, Heller ST, Nam K, Singh SB, Scapin G, Patel S, Thompson JE, Fitzgerald CE, O'Keefe SJ, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5809-13. Epub 2006 Aug 30. PMID:16945533

Page seeded by OCA on Tue Jul 29 11:44:49 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-==Overview==
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-p38 inhibitors based on 3,4-dihydropyrido[4,3-d]pyrimidazin-2-one template were synthesized and their SAR explored. Benchmark compounds 30, 35, and 36 were found to be potent against the enzyme. Crystal structure of p38 in complex with 30 indicated a key pi-stacking interaction with the pendant tyrosine residue-35 in the glycine-rich loop.
+The line below this paragraph, {{ABSTRACT_PUBMED_16945533}}, adds the Publication Abstract to the page
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 [[Category: Inhibitor design]]
 [[Category: Serine/threonine kinase]]
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