2bct: Difference between revisions

Revision as of 11:42, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2bct.png

Template:STRUCTURE 2bct

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENINTHE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

Template:ABSTRACT PUBMED 9298899

About this StructureAbout this Structure

2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899

Page seeded by OCA on Tue Jul 29 11:42:29 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''
+===THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN===
-==Overview==
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-Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.
+The line below this paragraph, {{ABSTRACT_PUBMED_9298899}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9298899}}
 ==About this Structure==
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 [[Category: Beta-catenin]]
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-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:07:22 2008''
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