2p8q: Difference between revisions

Revision as of 11:36, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2p8q.png

Template:STRUCTURE 2p8q

Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domainCrystal Structure of human Importin beta bound to the Snurportin1 IBB-domain

Template:ABSTRACT PUBMED 18187419

About this StructureAbout this Structure

2P8Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Molecular basis for the recognition of snurportin 1 by importin beta., Mitrousis G, Olia AS, Walker-Kopp N, Cingolani G, J Biol Chem. 2008 Jan 9;. PMID:18187419

Page seeded by OCA on Tue Jul 29 11:36:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain'''
+===Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain===
-==Overview==
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-The nuclear import of uridine-rich ribonucleoproteins (U snRNPs) is mediated by the transport adaptor snurportin 1 (SNP1). Similar to importin alpha, SNP1 uses an N-terminal importin beta binding (sIBB) domain to recruit the receptor importin beta and gain access to the nucleus. In this paper, we demonstrate the sIBB-domain has a bipartite nature, which contains two distinct binding determinants for importin beta. The first determinant spans residues 25-65, and includes the previously identified alphaIBB-region of homology. The second binding determinant encompasses residues 1-24 and resembles region 1011-1035 of the nucleoporin 153 (Nup153). The two binding determinants synergize within the sIBB-domain to confer a low nanomolar binding affinity for importin beta, (Kd ~2nM) in an interaction that, in vitro, is displaced by RanGppNHp. We propose that in vivo the synergy of Nup153 and nuclear RanGTP promotes translocation of U snRNPs into the nucleus.
+The line below this paragraph, {{ABSTRACT_PUBMED_18187419}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_18187419}}
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 [[Category: Protein transport]]
 [[Category: Snurportin]]
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