3c1v: Difference between revisions

Revision as of 11:35, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3c1v.png

Template:STRUCTURE 3c1v

The 1.5 A Crystal structure of Ca2+-bound S100A4The 1.5 A Crystal structure of Ca2+-bound S100A4

Template:ABSTRACT PUBMED 18435928

About this StructureAbout this Structure

3C1V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4., Gingras AR, Basran J, Prescott A, Kriajevska M, Bagshaw CR, Barsukov IL, FEBS Lett. 2008 May 28;582(12):1651-6. Epub 2008 Apr 22. PMID:18435928

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''The 1.5 A Crystal structure of Ca2+-bound S100A4'''
+===The 1.5 A Crystal structure of Ca2+-bound S100A4===
-==Overview==
+<!--
-S100A4 takes part in control of tumour cell migration and contributes to metastatic spread in in vivo models. In the active dimeric Ca(2+)-bound state it interacts with multiple intracellular targets. Conversely, oligomeric forms of S100A4 are linked with the extracellular function of this protein. We report the 1.5A X-ray crystal structure of Ca(2+)-bound S100A4 and use it to identify the residues involved in target recognition and to derive a model of the oligomeric state. We applied stopped-flow analysis of tyrosine fluorescence to derive kinetics of S100A4 activation by Ca(2+) (k(on)=3.5muM(-1)s(-1), k(off)=20s(-1)).
+The line below this paragraph, {{ABSTRACT_PUBMED_18435928}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_18435928}}
 ==About this Structure==
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 [[Category: Calcium-bound]]
 [[Category: S100a4]]
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