2h03: Difference between revisions

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{{Seed}}
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{{STRUCTURE_2h03|  PDB=2h03  |  SCENE=  }}  
{{STRUCTURE_2h03|  PDB=2h03  |  SCENE=  }}  


'''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''
===Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors===




==Overview==
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The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.
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{{ABSTRACT_PUBMED_16759857}}


==About this Structure==
==About this Structure==
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[[Category: Sulfamic acid]]
[[Category: Sulfamic acid]]
[[Category: Wpd-loop]]
[[Category: Wpd-loop]]
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