|
|
| Line 1: |
Line 1: |
| [[Image:2bsk.jpg|left|200px]] | | {{Seed}} |
| | [[Image:2bsk.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_2bsk| PDB=2bsk | SCENE= }} | | {{STRUCTURE_2bsk| PDB=2bsk | SCENE= }} |
|
| |
|
| '''CRYSTAL STRUCTURE OF THE TIM9 TIM10 HEXAMERIC COMPLEX'''
| | ===CRYSTAL STRUCTURE OF THE TIM9 TIM10 HEXAMERIC COMPLEX=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Import of proteins into mitochondria occurs by coordinated actions of preprotein translocases in the outer and inner membranes. Tim9 and Tim10 are translocase components of the intermembrane space, related to deafness-dystonia peptide 1 (DDP1). They coassemble into a hexamer, TIM9.10, which captures and chaperones precursors of inner membrane metabolite carriers as they exit the TOM channel in the outer membrane. The crystal structure of TIM9.10 reveals a previously undescribed alpha-propeller topology in which helical "blades" radiate from a narrow central pore lined with polar residues. The propeller blades are reminiscent of "tentacles" in chaperones Skp and prefoldin. In each TIM9.10 subunit, a signature "twin CX3C" motif forms two intramolecular disulfides. There is no obvious binding pocket for precursors, which we suggest employ the chaperone-like tentacles of TIM9.10 as surrogate lipid contacts. The first reported crystal structure of a mitochondrial translocase assembly provides insights into selectivity and regulation of precursor import.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16387659}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16387659 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_16387659}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 29: |
Line 33: |
| [[Category: Protein transport]] | | [[Category: Protein transport]] |
| [[Category: Tim9,tim10,mitochondrial protein import,tim complex]] | | [[Category: Tim9,tim10,mitochondrial protein import,tim complex]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:44:33 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:36:10 2008'' |