2d10: Difference between revisions

Revision as of 09:58, 29 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:2d10.png

Template:STRUCTURE 2d10

Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptideCrystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide

Template:ABSTRACT PUBMED 16615918

About this StructureAbout this Structure

2D10 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for NHERF recognition by ERM proteins., Terawaki S, Maesaki R, Hakoshima T, Structure. 2006 Apr;14(4):777-89. PMID:16615918

Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF)., Terawaki S, Maesaki R, Okada K, Hakoshima T, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):177-9. Epub 2002, Dec 19. PMID:12499563

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain., Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T, EMBO J. 2000 Sep 1;19(17):4449-62. PMID:10970839

Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex., Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T, EMBO J. 2003 Feb 3;22(3):502-14. PMID:12554651

Page seeded by OCA on Tue Jul 29 09:58:48 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2d10.gif|left|200px]]
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 {{STRUCTURE_2d10|  PDB=2d10  |  SCENE=  }}
-'''Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide'''
+===Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide===
-==Overview==
+<!--
-The Na+/H+ exchanger regulatory factor (NHERF) is a key adaptor protein involved in the anchoring of ion channels and receptors to the actin cytoskeleton through binding to ERM (ezrin/radixin/moesin) proteins. NHERF binds the FERM domain of ERM proteins, although NHERF has no signature Motif-1 sequence for FERM binding found in adhesion molecules. The crystal structures of the radixin FERM domain complexed with the NHERF-1 and NHERF-2 C-terminal peptides revealed a peptide binding site of the FERM domain specific for the 13 residue motif MDWxxxxx(L/I)Fxx(L/F) (Motif-2), which is distinct from Motif-1. This Motif-2 forms an amphipathic alpha helix for hydrophobic docking to subdomain C of the FERM domain. This docking causes induced-fit conformational changes in subdomain C and affects binding to adhesion molecule peptides, while the two binding sites are not overlapped. Our studies provide structural paradigms for versatile ERM linkages between membrane proteins and the cytoskeleton.
+The line below this paragraph, {{ABSTRACT_PUBMED_16615918}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16615918 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16615918}}
 ==About this Structure==
@@ Line 20: / Line 24: @@
 ==Reference==
 Structural basis for NHERF recognition by ERM proteins., Terawaki S, Maesaki R, Hakoshima T, Structure. 2006 Apr;14(4):777-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615918 16615918]
+Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF)., Terawaki S, Maesaki R, Okada K, Hakoshima T, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):177-9. Epub 2002, Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12499563 12499563]
+Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain., Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T, EMBO J. 2000 Sep 1;19(17):4449-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10970839 10970839]
+Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex., Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T, EMBO J. 2003 Feb 3;22(3):502-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12554651 12554651]
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
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 [[Category: Terawaki, S.]]
 [[Category: Protein-peptide complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:29:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:58:48 2008''