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-[[Image:1nz7.jpg|left|200px]]
+{{Seed}}
+[[Image:1nz7.png|left|200px]]
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 {{STRUCTURE_1nz7|  PDB=1nz7  |  SCENE=  }}
-'''POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.'''
+===POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.===
-==Overview==
+<!--
-We have previously reported a novel series of oxalyl-aryl-amino benzoic acid-based, catalytic site-directed, competitive, reversible protein tyrosine phosphatase 1B (PTP1B) inhibitors. With readily access to key intermediates, we utilized a solution phase parallel synthesis approach and rapidly identified a highly potent PTP1B inhibitor (19, K(i)=76 nM) with moderate selectivity (5-fold) over T-cell PTPase (TCPTP) through interacting with a second phosphotyrosine binding site (site 2) in the close proximity to the catalytic site.
+The line below this paragraph, {{ABSTRACT_PUBMED_12749891}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12749891 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12749891}}
 ==About this Structure==
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 [[Category: Oxamic acid inhibitor bound to p-loop]]
 [[Category: Protein tyrosine phosphatase fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:09:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:51:19 2008''